Both categories and quantities of lncRNAs are high in mammalian brain, which is one of the organs that is highly susceptible to aging. However, many lncRNAs remain uncharacterized and the roles of most lncRNAs have not been studied in brain aging. Through microarray and RNA-Seq screening with young and old mouse brains, we have identified several candidate lncRNAs that play roles in brain aging. Using multiple methods, including FISH, ChIRP-MS, RIP combining with knockdown and knockout models, we are dissecting the function and underlying mechanism of these lncRNAs in brain aging.