Oral Presentation 16th Asian Conference on Transcription 2019

The function of lncRNAs in brain aging (1166)

Fei Wang 1 , Amr R Ghanam 1 , Baowei Liu 1 , Shengwei Ke 1 , Ke Zhang 1 , Shuya Zhang 1 , Sisi Ma 2 , Juan Shi 1 , Xiaoyuan Song 1
  1. School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China
  2. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing , 100005, China

Both categories and quantities of lncRNAs are high in mammalian brain, which is one of the organs that is highly susceptible to aging. However, many lncRNAs remain uncharacterized and the roles of most lncRNAs have not been studied in brain aging.  Through microarray and RNA-Seq screening with young and old mouse brains, we have identified several candidate lncRNAs that play roles in brain aging. Using multiple methods, including FISH, ChIRP-MS, RIP combining with knockdown and knockout models, we are dissecting the function and underlying mechanism of these lncRNAs in brain aging.